GI Restore – Gut Lining & Digestive Tract Repair Supplement

GI Restore – Gut Lining & Mucosal Support

Support your gut from the inside out!

GI Restore is a comprehensive blend of amino acids, botanicals, and minerals that help maintain the integrity of the gut lining, promote healthy digestion, and soothe inflammation. Whether you’re dealing with occasional GI discomfort or rebuilding from the inside out, this formula offers foundational support for optimal gut health.

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Benefits

Rejuvenates and protects the intestinal lining
Promotes healthy gut function and regularity
Supports a balanced inflammatory response
Encourages gut-associated immune system resilience
Helps maintain optimal digestive and bowel health

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What’s Inside

A powerful combination of amino acids, botanical extracts, and nutrients to support gut integrity, calm inflammation, and nourish the intestinal lining.

Key Ingredients:

L-Glutamine – Fuels intestinal cells, aids healing, and reduces gut permeability
Zinc L-Carnosine – Promotes mucosal healing and reduces GI inflammation
N-Acetyl Glucosamine (GlcNAc) – Strengthens intestinal cell walls and modulates inflammation
MSM + Quercetin – Anti-inflammatory agents that help maintain intestinal barrier function
DGL, Aloe Vera, Slippery Elm, Marshmallow, Cat’s Claw, Chamomile, Okra – A soothing blend of mucilaginous herbs that calm and coat the intestinal tract
Mucin – Supports the mucosal barrier, enhancing gut immunity
Prune Powder + Citrus Pectin – Provide gentle, natural bowel regularity

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How to Use

Take 7 capsules per day or as directed by your health-care practitioner. For best results, use in conjunction with a gut-focused lifestyle and dietary protocol, such as our Gut Restoration Program.

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What to Avoid

* Do not take if you have a shellfish allergy.

Consult with your health-care practitioner about your specific circumstances and any questions you may have about this product.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Purity & Safety

Gluten-Free
Dairy-Free
Soy-Free
Non-GMO
Made with non-GMO ingredients and free of harsh laxatives or artificial additives
Composed of clinically studied ingredients in bioavailable forms

Research:
1. Mahmood, A., FitzGerald, A. J., Marchbank, T., Ntatsaki, E., Murray, D., Ghosh, S., & Playford, R. J. (2007). Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut, 56(2), 168–175. doi:10.1136/gut.2006.099929.

2. Davison, G., Marchbank, T., March, D. S., Thatcher, R., & Playford, R. J. (2016). Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. American Journal of Clinical Nutrition, 104(2), 526-536. doi: 10.3945/ajcn.116.134403.

3. Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007;56(2):168–175. doi:10.1136/gut.2006.099929.

4. Watari I, Oka S, Tanaka S, et al. Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study. BMC Gastroenterol. 2013;13:108.doi:10.1186/1471-230X-13-108.

5. Matsukura T, Tanaka H. Applicability of zinc complex of L-carnosine for medical use. Biochemistry (Mosc). 2000Jul;65(7):817-23.

6. Hudson T. Nutrient Profile: Zinc-Carnosine. Natural Medicine Journal. November 2013 Vol. 5 Issue 11.

7. Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., & Newsholme, P. (2018). Glutamine: Metabolism and immune function, supplementation and clinical ratnslation. Nutrients, 10(11). doi:10.3390/nu10111564.

8. Achamrah, N., Déchelotte, P., & Coëffier, M. (2017). Glutamine and the regulation of intestinal permeability:

from bench to bedside. Current Opinion in Clinical Nutrition and Metabolic Care, 20(1), 86-91. doi: 10.1097/MCO.0000000000000339.

9. Shu, X. L., Yu, T. T., Kang, K., & Zhao, J. (2016). Effects of glutamine on markers of intestinal inflammatory response and mucosal permeability in abdominal surgery patients: A meta-analysis. Experimental and Therapeutic Medicine, 12(6), 3499–3506. doi:10.3892/etm.2016.3799.

10. Zuhl, M. N., Lanphere, K. R., Kravitz, L., Mermier, C. M., Scheider, S., Dokladny, K., & Moseley, P. L. (2014). Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression. Journal of Applied Physiology, 116(2):183-191. doi: 10.1152/japplphysiol.00646.2013

11. Morris G, Berk M, Carvalho AF et al. The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome. Curr Pharm Des. 2016;22(40):6058-6075. DOI: 10.2174/1381612822666160914182822.

12. Sturgeon C, Fasano A. Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers. 2016;4(4):e1251384. doi:10.1080/21688370.2016.1251384.

13. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011 Jan;91(1):151-75. doi: 10.1152/physrev.00003.2008.

14. Shaik, Y., Caraffa, A., Ronconi, G., Lessiani, G., & Conti, P. (2018). Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin. Central-European Journal of Immunology, 43(4), 476–481. doi:10.5114/ceji.2018.81347

15. Kawabata, K., Mukai, R., & Ishisaka, A. (2015). Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Food & Function, 6(5), 1399-1417. doi: 10.1039/c4fo01178c.

16. Kim, J. E., Lee, M. R., Park, J. J., Choi, J. Y., Song, B. R., Son, H. J., … Hwang, D. Y. (2018). Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. Pharmaceutical Biology, 56(1), 309–317. doi:10.1080/13880209.2018.1474932.

17. Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and safety of a novel dietary supplement. Nutrients, 9(3), 1-21. doi:10.3390/nu9030290.

18. Sicard, J. F., Vogeleer, P., Le Bihan, G., Rodriguez Olivera, Y., Beaudry, F., Jacques, M., & Harel, J. (2018). N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli. Gut Pathogens, 10, 1-10. doi:10.1186/s13099-018-0252-y.

19. Baudoin, L., & Issad, T. (2015). O-GlcNAcylation and inflammation: A vast territory to explore. Frontiers in Endocrinology, 5, 1-8. doi:10.3389/fendo.2014.00235.

20. Yang, R., Yuan, B. C., Ma, Y. S., Zhou, S., Liu, Y. (2017). The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharmaceutical Biology, 55(1), 5-18. doi: 10.1080/13880209.2016.1225775.

21. Peterson, C. T., Sharma, V., Uchitel, S., Denniston, K., Chopra, D., Mills, P. J., & Peterson, S. N. (2018). Prebiotic potential of herbal medicines used in digestive health and disease. Journal of Alternative and Complementary Medicine (New York, N.Y.), 24(7), 656–665. doi:10.1089/acm.2017.0422.

22. Deters, A., Zippel, J., Hellenbrand, N., Pappai, D., Possemeyer, C., & Hensel, A. (2010). Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro. Journal of Ethnopharmacology, 127(1), 62-69. doi: 10.1016/j.jep.2009.09.050.

23. Alani, B., Zare, M., & Noureddini, M. (2015). Bronchodilatory and B-adrenergic effects of methanolic and aqueous extracts of Althaea root on isolated tracheobronchial smooth rat muscle. Advanced Biomedical Research, 4, 78.

doi:10.4103/2277-9175.153905.

24. Menghini, L., Ferrante, C., Leporini, L., Recinella, L., Chiavaroli, A., Leone, S., … Brunetti, L. (2016). An hydroalcoholic chamomile extract modulates inflammatory and immune response in HT29 cells and isolated rat colon. Phytotherapy Research, 30(9), 1513-1518. doi: 10.1002/ptr.5655.

25. Hajaji, S., Jabri, M. A., Alimi, D., Rekik, M., & Akkari, H. (2019). Chamomile methanolic extract mitigates small bowel inflammation and ROS overload related to the intestinal nematodes infection in mice. Acta Parasitologica, 64(1), 152-161. doi: 10.2478/s11686-019-00027-x.

26. Ortaç, D., Cemek, M., Karaca, T., Büyükokuroğlu, M. E., Özdemir, Z. Ö., Kocaman, A. T., & Göneş, S. (2018). In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions. Pharmaceutical Biology, 56(1), 165–175. doi:10.1080/13880209.2018.1442481.

27. Serrano, A., Ros, G., & Nieto, G. (2018). Bioactive compounds and extracts from traditional herbs and their potential anti-inflammatory health effects. Medicines (Basel, Switzerland), 5(3), 1-9. doi:10.3390/medicines5030076.

28. Kim YS, Ho SB. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep. 2010;12(5):319–330. doi:10.1007/s11894-010-0131-2.

29. Corfield, A. P. (2015). Mucins: a biologically relevant glycan barrier in mucosal protection. Biochimica et Biophysica Acta, 1850(1), 236-252. doi: 10.1016/j.bbagen.2014.05.003.

30. Behera SK, Praharaj AB, Dehury B, Negi S. Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases. Glycoconj J. 2015 Nov;32(8):575-613. doi: 10.1007/s10719-015-9606-6.

31. Lever, E., Scott, S. M., Louis, P., Emery, P. W. & Whelan, K. (2019). The effect of prunes on stool output, gut transit

time and gastrointestinal microbiota: A randomised controlled trial. Clinical Nutrition, 38(1), 165 – 173. doi: https://doi. org/10.1016/j.clnu.2018.01.003.

32. Ferreira-Lazarte, A., Moreno, F. J., Cueva, C., Gil-Sánchez, I., & Villamiel, M. (2019). Behaviour of citrus pectin during its gastrointestinal digestion and fermentation in a dynamic simulator (simgi®). Carbohydrate Polymers, 207, 382-390. doi: 10.1016/j.carbpol.2018.11.088.

33. Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA et al. Chemical composition and potential health effects of prunes: a functional food? Crit Rev Food Sci Nutr. 2001 May;41(4):251-86. DOI: 10.1080/20014091091814.

34. Lever E, Scott SM, Louis P et al. The effect of prunes on stool output, gut transit time and gastrointestinal microbiota: A randomised controlled trial. Clin Nutr. 2019 Feb;38(1):165-173. doi: 10.1016/j.clnu.2018.01.003.

35. Gill SK, Lever E, Emery PW, Whelan K. Nutrient, fibre, sorbitol and chlorogenic acid content of prunes (Prunus domestica): an updated analysis and comparison of different countries of origin and database values. Int J Food Sci Nutr. 2019 Dec;70(8):924-931. doi: 10.1080/09637486.2019.1600664.