Benefits

• Promotes healthy liver function and detoxification
• Supports antioxidant status and balanced inflammatory response
• Encourages glutathione production, your body’s master antioxidant
• Aids in healthy lipid metabolism and cholesterol levels
• Helps maintain a healthy response to environmental stressors

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What’s Inside

Cordyceps (CordycepsPrime™)

A medicinal mushroom rich in bioactive compounds like adenosine and cordycepin. Supports antioxidant activity, liver protection, and balanced lipid metabolism.

Reishi Mushroom Blend (Ganoderma lucidum, applanatum, tsugae)

Triterpenes and polysaccharides in these mushrooms help promote antioxidant activity and normal liver enzyme function. Studies show support for healthy cholesterol and liver protection.

Milk Thistle (Silymarin Complex)

A liver-supporting botanical known to protect against toxins, promote a healthy inflammatory response, and assist in glutathione recycling.

N-Acetyl-L-Cysteine (NAC)

A potent precursor to glutathione, NAC plays a critical role in antioxidant defense, liver detox, and reducing oxidative stress.

Chinese Skullcap (Scutellaria baicalensis)

Supports antioxidant activity, liver cell protection, and lipid metabolism via its rich flavonoid content.

Schisandra Extract

An adaptogenic fruit that promotes liver regeneration, antioxidant status, and helps prevent oxidative liver damage.

Burdock Root Extract

Traditionally used to support the liver and lymphatic systems. Aids in healthy inflammation regulation and toxin clearance.

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How to Use

Take 4 capsules per day or as directed by your health-care practitioner. For best results, pair with our Gut Restoration Bundle or other foundational supplements as part of a 28-day reset.

Servings

120 capsules / 30 servings

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What to Avoid

Consult with your health-care practitioner before use if you are pregnant, nursing, or taking any prescription medications.

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Purity and Safety

Detox + is formulated with high-quality, non-GMO ingredients and contains no gluten, dairy, or soy. Mushrooms and herbs are tested for purity and potency, and all extracts are sourced from reputable, BSE-free origins.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research:

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2. Lo HC, Hsieh C, Lin FY, Hsu TH. A systematic review of the mysterious caterpillar fungus Ophiocordyceps sinensis

in Dong‑ChongXiaCao ( Dōng Chóng Xià Cǎo) and related bioactive ingredients. J Tradit Complement Med. 2013;3(1):16‑32. doi:10.4103/2225‑4110.106538.

3. Wang Y, Wang Y, Liu D, et al. Cordyceps sinensis polysaccharide inhibits PDGF‑BB‑induced inflammation and ROS production in human mesangial cells. Carbohydr Polym. 2015;125:135‑145. doi:10.1016/j.carbpol.2015.02.012.

4. Lee EJ, Jang KH, Im SY, et al. Physico‑chemical properties and cytotoxic potential of Cordyceps sinensis

metabolites. Nat Prod Res. 2015;29(5):455‑459. doi:10.1080/14786419.2014.948438.

5. Li T, Wen L, Cheng B. Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via

PKA/mTOR pathway. Biochem Biophys Res Commun. 2019;516(3):632‑638. doi:10.1016/j.bbrc.2019.06.108.

6. Lan T, Yu Y, Zhang J, et al. Cordycepin ameliorates Nonalcoholic Steatohepatitis by activation of the AMP‑activated protein kinase signaling pathway. Hepatology. 2021;74(2):686‑703. doi:10.1002/hep.31749.

7. Cheng YJ, Cheng SM, Teng YH, Shyu WC, Chen HL, Lee SD. Cordyceps sinensis prevents apoptosis in mouse liver

with D‑galactosamine/lipopolysaccharide‑induced fulminant hepatic failure. Am J Chin Med. 2014;42(2):427‑441.doi:10.1142/S0192415X14500281.

8. Chen L, Zhang L, Wang W, et al. Polysaccharides isolated from Cordyceps sinensis contribute to the progression

of NASH by modifying the gut microbiota in mice fed a high‑fat diet. PLoS One. 2020;15(6):e0232972. doi:10.1371/journal.pone.0232972.

9. Chiu HF, Fu HY, Lu YY, et al. Triterpenoids and polysaccharide peptides‑enriched Ganoderma lucidum: a randomized, double‑blind placebo‑controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol. 2017;55(1):1041‑1046. doi:10.1080/13880209.2017.1288750.

10. Wu X, Zeng J, Hu J, et al. Hepatoprotective effects of aqueous extract from Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) on α‑amanitin‑induced liver injury in mice. Int J Med Mushrooms. 2013;15(4):383‑391. doi:10.1615/intjmedmushr.v15.i4.60.

11. Chen YS, Chen QZ, Wang ZJ, Hua C. Anti‑inflammatory and hepatoprotective effects of Ganoderma

lucidum polysaccharides against carbon tetrachloride‑induced liver injury in kunming mice. Pharmacology. 2019;103(3‑4):143‑150. doi:10.1159/000493896.

12. Hu Z, Du R, Xiu L, et al. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide‑induced inflammatory responses and acute liver injury. Cytokine. 2020;127:154917. doi:10.1016/j.cyto.2019.154917.

13. Zhao C, Fan J, Liu Y, et al. Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol‑induced liver injury in mice, an iTRAQ‑based proteomic analysis. Food Chem. 2019;271:148‑156. doi:10.1016/j.foodchem.2018.07.115

14. Liang Z, Yuan Z, Li G, Fu F, Shan Y. Hypolipidemic, antioxidant, and antiapoptotic effects of polysaccharides extracted from reishi mushroom, Ganoderma lucidum (Leysser: Fr) karst, in mice fed a high‑fat diet. J Med Food. 2018;21(12):1218‑1227. doi:10.1089/jmf.2018.4182.

15. Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32(11):2202‑2213.

doi:10.1002/ptr.6171.

16. Federico A, Dallio M, Loguercio C. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017;22(2):191. doi:10.3390/molecules22020191.

17. Tao L, Qu X, Zhang Y, Song Y, Zhang SX. Prophylactic therapy of silymarin (Milk Thistle) on antituberculosis drug‑induced liver injury: a meta‑analysis of randomized controlled trials. Can J Gastroenterol Hepatol. 2019;2019:3192351. doi:10.1155/2019/3192351.

18. Zhong S, Fan Y, Yan Q, et al. The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: a meta‑analysis (PRISMA) of randomized control trials. Medicine (Baltimore). 2017;96(49):e9061.doi:10.1097/MD.0000000000009061.

19. Luczak MW, Zhitkovich A. Role of direct reactivity with metals in chemoprotection by N‑acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). Free Radic Biol Med. 2013;65:262‑269.doi:10.1016/j.freeradbiomed.2013.06.028.

20. Mlejnek P, Dolezel P, Maier V, Kikalova K, Skoupa N. N‑acetylcysteine dual and antagonistic effect on cadmium cytotoxicity in human leukemia cells. Environ Toxicol Pharmacol. 2019;71:103213. doi:10.1016/j.etap.2019.103213.

21. Joshi D, Kumar MD, Kumar SA, Sangeeta S. Reversal of methylmercury‑induced oxidative stress, lipid peroxidation, and DNA damage by the treatment of N‑acetyl cysteine: a protective approach. J Environ Pathol Toxicol Oncol. 2014;33(2):167‑182. doi:10.1615/jenvironpatholtoxicoloncol.2014010291.

22. Walayat S, Shoaib H, Asghar M, Kim M, Dhillon S. Role of N‑acetylcysteine in non‑acetaminophen‑related acute

liver failure: an updated meta‑analysis and systematic review. Ann Gastroenterol. 2021;34(2):235‑240. doi:10.20524/aog.2021.0571.

23. Wang ZL, Wang S, Kuang Y, Hu ZM, Qiao X, Ye M. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Biol. 2018;56(1):465‑484. doi:10.1080/13880209.2018.1492620.

24. Dai J, Liang K, Zhao S, et al. Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet‑induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A. 2018;115(26):E5896‑E5905. doi:10.1073/pnas.1801745115.

25. Chen Q, Liu M, Yu H, et al. Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK‑mediated SREBP signaling pathway. J Nat Med. 2018;72(3):655‑666. doi:10.1007/s11418‑018‑1199‑5.

26. Yuan R, Tao X, Liang S, et al. Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol‑induced liver injury through reducing CYP2E1‑dependent oxidative stress. Biomed Pharmacother.2018;99:537‑542. doi:10.1016/j.biopha.2018.01.079.

27. Park HJ, Lee SJ, Song Y, et al. Schisandra chinensis prevents alcohol‑induced fatty liver disease in rats. J Med Food. 2014;17(1):103‑110. doi:10.1089/jmf.2013.2849.

28. Gao Q, Yang M, Zuo Z. Overview of the anti‑inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol Sin. 2018;39(5):787‑801. doi:10.1038/aps.2018.32.

29. Romualdo GR, Silva EDA, Da Silva TC, et al. Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide‑induced model of steatohepatitis‑associated hepatocarcinogenesis. Environ Toxicol. 2020;35(4):518‑527. doi:10.1002/tox.22887.